Evidence
SomaBiome is grounded in peer-reviewed microbiome research across fibromyalgia and chronic pain conditions.
Selected Publications
Fibromyalgia
PAIN, 2019
Altered microbiome composition in individuals with fibromyalgia
Identified species-level microbiome alterations associated with symptom severity and metabolomic shifts in a case-control cohort.
Chronic Pain Generalization
Anesthesiology, 2025
Gut microbiome signatures in Complex Regional Pain Syndrome (CRPS)
Demonstrated reproducible microbiome signatures across independent cohorts and geographies, suggesting a generalized signal for chronic pain.
Mechanistic Validation
Gut, 2023
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines
Used preoperative colorectal cancer stool samples to test causality via fecal microbiota transplantation in mice. Identified Alistipes onderdonkii (increased leak risk) and Parabacteroides goldsteinii (improved healing via anti-inflammatory effects), linking microbiome composition to mucosal inflammatory signaling.
Selected coverage
- Nature News — "Baffling chronic pain eases after doses of gut microbes" (Apr 24, 2025) — https://doi.org/10.1038/d41586-025-01290-x
- Nature Outlook: Pain — "The gut microbiome and chronic pain" (Sep 25, 2024) — https://doi.org/10.1038/d41586-024-03006-z
Media coverage discusses peer-reviewed research and does not constitute endorsement or clinical validation of any product.
Performance & Translation
Across published research cohorts, microbiome-based classifiers show ~90% case–control performance in retrospective research settings. SomaBiome is translating these findings into clinical decision support under development, designed for integration into routine clinic workflows.
Disclaimer: Performance metrics refer to retrospective analysis in research cohorts. Clinical validation in prospective real-world settings is ongoing. Not for consumer use.